Pharos is a web resource that originated from the NIH "Illuminating the Druggable Genome" (IDG) program to characterize the understudied regions of the druggable genome. These so-called “dark” regions are important because they have potential druggable opportunities toward a wide range of disease areas. Pharos is built on top of the Target Central Resource Database (TCRD), and the most recent update for TCRD now incorporates 78 disparate data sources, incorporating target expression, protein-protein interaction, disease ontology and chemical activity databases. These data have served to bolster our current knowledge base, and with this enhancement, Pharos now enables users to explore subsets of related targets, as well as view their similarity overlap. In addition to improvements to the user interface, Pharos has also implemented a GraphQL API, allowing fine grained queries that give users more control over the data fetched than over a standard REST API. <br/>A useful approach in target illumination is to find dark targets that are similar to more well studied targets, and the central aim of Pharos continues to be enriching knowledge around human targets and monitoring their therapeutic development levels. By continually incorporating new data sets, Pharos allows for more unique combinations of data and facilitates the discovery of interesting related targets and shows connections from diseases to targets to ligands.

Pharos: An open data resource for examining target, disease and ligand interactions

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.