Platinum-based anticancer drugs are widely used in cancer therapy. Five main platinum-based anticancer drugs are cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin. Cisplatin is applied to treat a variety of types of cancers such as testicular, ovarian, etc. The relationship cisplatin and DNA linkage is well documented, and it is responsible for DNA cross-linking, As a result of DNA cross linkage is inhibation of DNA replication. This study hypothesizes that cisplatin will have a different absorption wavelength than transplatin. To test the hypothesis, UV-vis spectroscopy is used to identify the wavelengths of both isomers of diamminedichloroplatinum(II). This method of identification is low cost and highly effective due to its mechanism; therefore, it is an efficient way to distinguish cisplatin in the pure solution and a mixture with complex biological substances, such as blood and urine. The results of this study suggest that cisplatin is identified in cases of DNA presence by using UV-vis spectroscopy. These results cannot determine if cisplatin can be identified in a pure solution. On this basis, UV-vis spectroscopy can be used to observe changes in the wavelength of cisplatin due to the concentration of DNA. These changes cannot be observed with transplatin due to its inability to inhibit DNA replication.

Ultraviolet-visble spectroscopic procedure to separate a mixture of Cis- Pt(NH3)2Cl2 anti-tumor drug and biological substances

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.