The substituted pyrazoles with aromatic and heteroaromatic groups possess numerous biological activities, which makes them particularly interesting. Continuous efforts have been devoted to the development of general and versatile synthetic methodologies to this class of compounds. The existing methods suffered with some drawbacks such as longer reaction times, undesired products formation, and thus difficulty in product isolation and purification. Accordingly, we chose to develop microwave assisted synthetic methods to access these highly useful heterocyclic compounds. We have recently developed an efficient microwave assisted synthetic approach by optimizing the reaction conditions such as solvent, microwave power and reaction time. A series of pyrazole compounds were prepared using arylhydrazines and dicarbonyl compounds. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and GC-MS analysis and evaluated for in vitro anticancer activity against human melanoma (A375 and SK-Mel-28) and nonmelanoma (A431) cancer cells. Pre-treatment with all compounds exhibited significant decrease in cell growth/viability with minimal effects on keratinocytes (HaCat cells). Some of these compounds displayed relatively low micromolar anticancer activity. Synthetic methods, structural characterization and biological activity data from cytotoxicity assay will be presented in the poster.

Synthesis and biological evaluation of 1,3-diarylpyrazoles: In vitro cytotoxicity studies on human melanoma and nonmelanoma cancer cells

ACS Spring Meeting 2021

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