RNA-dependent RNA polymerase is an enzyme that has received attention as a drug target for a variety of viruses that infect humans, including influence, polio, and hepatitis C. More recently, RNA polymerase inhibitors have been investigated as potential treatments for SARS-CoV-2, and remdesivir, a nucleoside analog originally developed to treat the Ebola virus, received emergency use authorization from the FDA in 2020. We performed virtual screening using Dock Blaster to search for novel compounds that can inhibit the RNA polymerase of SARS-CoV-2. The top hits were then profiled to determine which ones are the most promising for future testing in biological assays.

Inhibitors of SARS-CoV-2 RNA polymerase identified by virtual screening

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.