Because of potential advantages in cost, sustainability and most importantly, new chemistry, there has been ongoing interest in catalysis with Earth-abundant metals such as iron, cobalt and nickel. One limitation in catalyst discovery has been the availability of reliable metal precursors for rapid catalyst discovery. Our laboratory has been engaged in developing new coordination and organometallic compounds of these metals that enable catalyst discovery by high throughput experimentation. Catalysts for the asymmetric hydrogenation of alkenes, Suzuki-Miyaura cross coupling and C–H borylation have been discovered using this approach. The role of industrial collaborations as well as mechanistic advances and unexpected findings will be highlighted.

High throughput experimentation as a tool for catalyst discovery with earth abundant transition metals

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.