Luminogenic bioorthogonal probes have emerged as useful biological tools to selectively visualize biomolecules in complex cellular environments through “turn-on” emission. Recently, there has been much interest in the design of luminogenic bioorthogonal probes that rely on the efficient emission quenching effect and chemical reactivity of tetrazine derivatives. Herein, we report the synthesis, characterization, and photophysical studies of three novel luminogenic cyclometalated iridium(III) bis-tetrazine complexes. These complexes were utilized as luminogenic double-clicking two-point binders for the derivatives of a strained alkyne, bicyclo[6.1.0]non-4-yne (BCN). The cellular uptake efficiency, bioimaging capability, and (photo)cytotoxicity of the complexes were also studied by ICP-MS, confocal microscopy, and MTT assays, respectively.

Luminogenic Iridium(III) Bis-tetrazine Complexes as Double-Clicking Two-point Binders and Bioorthogonal Probes for Bioimaging and Photocytotoxic Applications

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