A series of blue-green emitting RuII diisocyano complexes containing 2-benzoxazol-2-ylphenolate (PBO) have been prepared. The complexes were isolated under varied reaction conditions in two isomeric forms, i.e. trans, trans, trans- (1) and cis, trans, cis- (2), with varied ligand coordination geometry above the RuII center. The photophysical properties of the isomeric complexes have been compared and tuned by the systematic variation of the electronic properties of the isocyanides. The cis, trans, cis- (2) isomer exhibit structureless emission in the blue-green region (471 − 517 nm) upon excitation at λex > 400 nm in dichloromethane solution at room temperature. Both isomeric forms show similarly structured greenish emission at 500 – 540 nm on excitation at λex > 355 nm in methanol/ethanol (4:1) glassy medium at 77 K. Cytotoxicity of the complexes have also been studied. The antiproliferative activities of the complexes were determined for eight human cancer cell lines and compared with cisplatin by means of MTT assay. The trans, trans, trans- (1a – b) isomers are found to exhibit significant in vitro cytotoxicity, with IC50 value ranged between 3.51 to 6.45 µM. Soft agar colony-forming assay were also performed. The clonogenicity of NCI-H460 cell treated with 10 µM (1a) was significantly reduced to 5%. The cis, trans, cis- (2a – b), however, exhibit moderate to no effect to cancer cell (IC50 >100 µM).

Photophysical and Antitumor Properties of Ruthenium(II) Diisocyano Complexes Bearing 2-Benzoxazol-2-ylphenolate

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