The first general example of tetra-ortho-substituted biaryl synthesis via Suzuki-Miyaura cross coupling of potassium aryltrifluoroborates and (hetero)aryl chlorides is reported. In fact, organotrifluoroborates would serve as a better coupling partner than corresponding arylboronic acids for Suzuki-coupling due to no association of uncertain amount of boroxine. Its lower activity, however, would be a concern and thus leads such transformation remains challenging. Herein, a new class of tailor-made indolyl-phosphine ligand-palladium complex bearing a tunable tethered linkage is designed for tackling challenging tetra-ortho-substituted biaryl synthesis. With the metal complex of Pd2dba3/Nap-4-Ph, a wide range of sterically hindered chloroarenes were coupled-well with steric bulky aryltrifluoroborates in good-to-excellent yields (up to 99%) with catalyst loading down to 0.1 mol%.

New Palladium Complexes for Assembly of Highly Steric Hindered Biaryls

In order to view the entire gallery of posters, videos, and other materials, please click "Submissions" below.

To find the Q&A for each poster category, please click "Sessions" below. To ask a question, simply click on the category session; they are organized alphabetically by title. After clicking, you'll see a list of video presentations in the list to the right. Below each video area, you'll see a section entitled 'Q&A for this presentation:'. Here you'll be able to post questions to the authors. They'll be notified, and you'll also be notified when they reply to your question. You can expect that notification by email, and you'll find the author's response here. 

ACS Publications Symposium

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.