Background: The rising attention of MRI-based radiomics in nasopharyngeal carcinoma (NPC), have been shown not only among radiologists but also among oncologists. Aim of the review is to systematically evaluate the methodological quality of MRI-based radiomic studies of NPC and analysis of the publication journal characteristics. Methods: A systematic search was performed and the methodological quality of study included (=24) was evaluated according to the RQS (Radiomic quality score). Subgroup, for journal type (imaging/clinical) and biomarker (prognostic/predictive), and correlation, between RQS and journal Impact Factor(IF) and journal quartile and between IF and journal type/biomarker, were performed. Mann-Whitney-U test and Spearman’s correlation were performed. Results: The mean RQS was 7.5 ± 5.4. No studies reported a phantom study or a test re-test, biological correlation or open science data. No significant differences of RQS were detected between articles published in clinical/imaging journal and between studies with a predictive or prognostic biomarker as well as between total RQS and IF of the year of publication and journal quartile. A significant higher IF was found in radiomic studies published in clinical journal (p always < 0.05). Conclusions: Radiomic articles in NPC are mostly of low methodological quality, however they are of interest for clinicians.

**Background**: The rising attention of MRI-based radiomics in nasopharyngeal carcinoma (NPC), have been shown not only among radiologists but also among oncologists. Aim of the review is to systematically evaluate the methodological quality of MRI-based radiomic studies of NPC and analysis of the publication journal characteristics. **Methods**: A systematic search was performed and the methodological quality of study included (=24) was evaluated according to the RQS (Radiomic quality score). Subgroup, for journal type (imaging/clinical) and biomarker (prognostic/predictive), and correlation, between RQS and journal Impact Factor(IF) and journal quartile and between IF and journal type/biomarker, were performed. Mann-Whitney-U test and Spearman’s correlation were performed. **Results**: The mean RQS was 7.5 ± 5.4. No studies reported a phantom study or a test re-test, biological correlation or open science data. No significant differences of RQS were detected between articles published in clinical/imaging journal and between studies with a predictive or prognostic biomarker as well as between total RQS and IF of the year of publication and journal quartile. A significant higher IF was found in radiomic studies published in clinical journal (p always < 0.05). **Conclusions**: Radiomic articles in NPC are mostly of low methodological quality, however they are of interest for clinicians.

The use of Radiomic Quality Score (RQS) assessment in MRI based radiomics in nasopharyngeal cancer: systematic review and perspective.

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