*The study and application of computational design is gaining importance in biomedical engineering as medical devices are becoming more complex, especially with the emergence of 3D printed scaffold structures. Scaffolds are medical devices that act as temporary mechanical support and facilitate biological interactions to regenerate damaged tissues. Past computational design studies have investigated the influence of geometric design in lattice structured scaffolds to investigate mechanical and biological behavior. However, these studies often focus on symmetric cubic structures leaving an opportunity for investigating a larger portion of the design space to find favorable scaffold configurations beyond these constraints.  Here, tissue growth behavior is investigated for tetragonal Bravais lattice structured scaffolds by implementing a computational approach that combines a voxel-based design generation method, curvature-based tissue growth modeling, and a design mapping technique for selecting scaffold designs. Results show that tetragonal unit cells achieve higher specific tissue growth than cubic unit cells when controlled for beam width, thus demonstrating the merits in investigating a larger portion of the design space. Specifically, cubic structures achieve around 50% specific growth, while tetragonal structures achieve more than 60% specific growth for the design space investigated. These findings demonstrate the need for continued adaption and use of computational design methodologies for biomedical applications, where the discovery of favorable solutions may significantly improve medical outcomes.*


Computational Design Generation and Evaluation of Beam-Based Tetragonal Bravais Lattice Structures for Tissue Engineering

Division / Sponsors: 
Design Engineering Division and Computers & Information In Engineering Division


Paper Proceedings: https://asmedigitalcollection.asme.org/IDETC-CIE/IDETC-CIE2020/volume/83907

IDETC2020 - Virtual Conference

Supporting the need among researchers worldwide for additional online and multimedia content, ASME now offers the ASME Conference Video Collection. This platform will collect and provide long-term access to conference presentation videos, encompassing all technology areas within ASME's technical conference and events program. About 30,000-40,000 engineers across all mechanical engineering and related disciplines participate in ASME conferences each year. This includes authors of approximately 6,000 to 8,000 technical papers published by ASME, the majority of whom also submit video presentations for our virtual conferences. The video collection will be available as an add-on to existing product packages or as a separate subscription.