Pemphigus is an autoimmune blistering disease,through this hospital series,we aim to describe our clinic-therapeutic experience in pemphigus.We performed a unicentric retrospective study of all patients admitted to the university hospital IbnSina RabatMorocco with the diagnosis of pemphigus from 1990to2020(over30years).Inclusion criteria;age,gender,mean duration of the disease,mortality rate,treatment ,disease course.The diagnosis was mainly clinical and confirmed by histopathology,direct immunofluorescenceandindirect immunofluorescence.There were 302cases,26new patients in2020.The most common variant was pemphigus vulgaris125cases followed by pemphigus seborrheic99cases,foliaceous40 and vegetans27cases.sex-ratio 0.75,the average age;53yearsold,the mean duration of the disease before diagnosis was13,36months,severePDAI76%.Oral corticosteroids therapy prednisone was given to133 cases, methylprednisolone to12cases.Adjuvants therapy with azathioprine(93cases),disulone(22cases),cyclophosphamide(1case), methotrexate(2cases),rituximab(9cases),azathioprine and methotrexate(3cases),azathioprine and rituximab(3cases).Clinical remission (133cases) (meanduration2.5months),lost to follow-up(39cases);relapses(89cases)(meanduration51months),death(33cases).In our series, no statistical differences have been noted concerning the duration of the remission between oral steroids only and the association with a immunosuppressive agent.For economical reasons azathioprine is the most used sparing agent .The duration of treatment is very prolonged,we suggest a progressive tapering of steroids.Our recommendations to discontinue treatment in a patient with clinical remission on low doses of oral steroids is the absence of new lesions and circulating antibodies.Usually over than 2 years with a close monitoring of drugs side effects.

ESDR031 - Pemphigus:a morrocan retrospective study over 30years

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING