Atopic dermatitis (AD) is a chronic, debilitating, inflammatory skin disorder that can present a wide range of clinical manifestations along with quality of life (QoL) impairment in people of all ages. Herein, we aimed to characterize the influence of AD on health-related quality of life (HRQoL) in Bangladeshi adults. A cross-sectional study comprising 109 eligible adults (41 males and 68 females, mean age of 33.49 ± 14.87 years), conducted at a dermatology outpatients department in Dhaka. We adopted UK diagnostic criteria to determine the patient with AD. A structured questionnaire was administrated to obtain primary data on patients’ characteristics and Dermatology Life Quality Index (DLQI) for HRQoL. The severity of AD was measured by the self-reported global AD severity, and Eczema Area and Severity Index (EASI). The mean DLQI score for the entire sample was 10.31 ± 5.19, and 43.20% reported having a poor QoL. In multivariable regression models, both moderate and severe AD groups reported significantly higher DLQI score (Coef. = 3.04; 95% CI = 0.51-5.57, p = 0.019 and Coef. = 4.12; 95% CI = 1.58-6.66, p = 0.002 respectively) compare to that of mild group. Concurrently, we also observed a substantial increase in DLQI score along with increasing disease severity measured by EASI (Coef. = 0.50; 95% CI = 0.39-0.60, p < 0.001), suggesting that the higher the EASI score poorer the HRQoL. AD severity markedly impaired HRQoL in Bangladeshi adults. A more patient-centered approach in the management of AD would alleviate patients suffering and thereby improve HRQoL.

ESDR076 - Disease Severity Influencing Health-Related Quality of Life in Bangladeshi Adults with Atopic Dermatitis

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING