The objective was to evaluate health-related quality of life (HRQoL) in atopic dermatitis (AD) using EQ-5D-5L, EQ VAS, Skindex-16, Dermatology Life Quality Index (DLQI), and DLQI-Relevant (DLQI-R), and to determine convergent validity of these instruments. We also aimed to compare EQ-5D-5L dimension, index and EQ VAS scores of AD patients to those of patients with hidradenitis suppurativa (HS), pemphigus, psoriasis, and the age-matched general population. A multicentric, cross-sectional survey was conducted between 2018 and 2021 in Hungary. Disease severity was measured by SCORing Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Investigator Global Assessment (IGA) scales. A total of 218 adult patients (58% women, mean age 31 years) with mild to severe AD participated, mean EQ-5D-5L index, EQ VAS, Skindex-16, DLQI, and DLQI-R scores were 0.82±0.22, 69.15±20.5, 56.84±27.46, 13.44±8.46, and 13.76±8.6, respectively. The EQ-5D-5L index and EQ VAS showed strong correlations with Skindex-16, DLQI, and DLQI-R (range of r |0.62| to |0.75|). Regarding severity scores, weak correlations were observed with EQ-5D-5L (|0.30| to |0.36|) and moderate correlations with skin-specific instruments (0.43 to 0.53). Similar to patients with HS, EQ-5D-5L dimension scores in AD revealed more problems in the self-care, usual activities, pain/discomfort, and anxiety/depression dimensions than in pemphigus, psoriasis, or the general population. To conclude, a good convergent validity among EQ-5D-5L, EQ VAS, Skindex-16, DLQI, and DLQI-R was established; each instrument is suitable for use in AD however, skin-specific questionnaires correlate stronger with disease severity. The impairment of HRQoL in AD is comparable to HS and places a great burden on patients.

ESDR080 - The impact of atopic dermatitis on health-related quality of life

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING