In atopic dermatitis (AD) patients aeroallergens such as house dust mite contribute profoundly to the disease severity. Temperature-controlled laminar airflow (TLA) has been developed to reduce indoor allergen exposure during the night’s sleep by filtering the surrounding atmosphere. To investigate the clinical and immunological effects of TLA in adults with AD, we conducted an observational study with ten patients with moderate to severe AD sensitized to house dust mite. The patients used TLA for three months and were able to participate in a nine months extension phase. Physician's Global Assessment (PGA), SCORAD (41.96 ±9.78 vs. 34.15 ± 9.69, p = .037), and EASI (10.01 ± 3.94 vs 8.41 ± 3.76, P = .038) were significantly reduced after three months. Subjective scores such as sleeplessness and life quality measured by dermatology life quality index improved significantly. Investigating immunological effects, analysis of HDM stimulated PBMCs from patients revealed that the proliferative responses of total T cells, CD4+ T cells, skin-homing CD4+ T cells, and CD8+ T cells were significantly decreased after 3 months of TLA usage. Type 2 inflammation cytokines measured in patients’ serum were reduced in tendency after three months of TLA usage. After 12 months, consistent results were seen according to clinical disease scores and in vitro analyses. This is the first study suggesting beneficial effects of three months use of TLA in HDM sensitized adult AD patients regarding objective, subjective and in vitro parameters. Effects were consistent over one year of TLA. In sensitized AD patients, TLA may contribute to disease control and improvement as a potential add-on treatment.

ESDR081 - Observational study on temperature-controlled laminar airflow in atopic dermatitis patients

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING