Modified intermittent fasting (MIF) is associated with metabolic benefits, but its impact on psoriasis has not been explored yet. The MANGO trial investigates how 12 weeks MIF impacts skin, gut and metabolic health in psoriasis patients. Here we report the interim analysis of the crossover trial. A 2-arm pilot crossover randomized controlled trial is being performed. Subjects with mild psoriasis fast twice a week for 12 weeks and monitored another 12 weeks on standard diet. Data is collected on demographics, disease phenotype and activity, diet and exercise, and quality of life. Biochemical parameters in skin, gut and blood are being collected, including microbiotic, inflammatory, permeability and metabolic markers. A total of 24 subjects were enrolled, and one group of 12 participants has fasted for 12 weeks, whereas the other half has continued their regular diet. Fifteen subjects were female, the mean age was 46 years, and the mean Psoriasis Activity Score Index (PASI) was 3.80. In addition to PASI, disease activity was assessed subjectively. Fasting subjects reported improvement more frequently at weeks 6 and 12 (p<0.0001), mentioning less scaling and thickening. Objectively, PASI and Body Surface Area (BSA) did not differ significantly between fasting and regular diet, although both were reduced. Waist circumference and weight were comparable at 6 weeks but significantly reduced in the fasting group at week 12 (p<0,05 and <0,001, respectively). The interim analysis of 12 weeks MIF in psoriasis shows promising results yet remains to be confirmed with the final analysis and with other parameters. Moreover, it would be of great interest to observe which participant profiles were most successful to identify predictive factors. Insights from these data will aid us to understand the complexity of psoriasis and how dietary changes may impact the course of this chronic skin disease. If successful, fasting may be considered as an add-on treatment in psoriasis.

ESDR243 - Interim Results of the MANGO Trial: Modified Intermittent Fasting in Psoriasis

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING