Recent studies have focused on the negative effects of visible light (VL) on the skin, which lead to activation of metalloproteinases and oxidative stress induction, worsening clinical signs such as, melasma or post-inflammatory hyperpigmentation. The objective was to complete the existing scientific evidence of Fernblock® about its photoprotection potential against VL. We developed two in vitro studies, regarding physicochemical level protection and biological activity. Sunscreen formulations containing Fernblock® were selected and their transmittance of solar simulated VL was calculated by spectroradiometric measurement. In the second study, we examined Fernblock®’s action mechanism against blue light from digital devices on skin cells. All samples showed VL absorbance capacity above the levels established in the references consulted as proposals for VL-SPF. Regarding biological studies, treatment with Fernblock® prior to VL radiation prevents alteration of mitochondrial morphology and function in fibroblasts and significantly reduces the activation of opsin 3 in melanocytes and the photo-oxidation of melanin. We elucidate a scoring system to evaluate the photoprotection potential against VL consisting of different study levels from in vitro to clinical scientific evidence. Thus, Fernblock® added to different combinations of organic and mineral sunscreens can significantly increase visible light protection as demonstrated by both physiochemical and biological studies.

ESDR315 - Scoring Levels To Evaluate The Protective Effect Of The Aqueous Extract Of Polypodium Leucotomos (Fernblock®) Against Visible Light In Topical Formulations.

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING