Skin aging is a multifactorial process which is segmented into two major categories: intrinsic (or chronological aging) and extrinsic aging (due to external factors). Regardless of the type of aging, many mechanisms overlap resulting in the loss of critical structure due to lower production of extracellular matrix (ECM) proteins such as collagen as well as altered content of certain glycosaminoglycans (such as hyaluronic acid) and functional elastin. This leads to loss of activity and structural support. Many cosmetic products attempt to restore the youthful structure and appearance of skin (translating as lessened lines & wrinkles, firmness, suppleness, elasticity, etc.). However, in order to properly target these structural elements, it is critical to consider the formulation parameters and actual delivery of the active ingredients to achieve such results. Here, we assess the effect when a formula contains specifically paired delivery systems with the anti-aging ingredients. In order to assess this delivery effect, we tested 2 different formulae (one with specific delivery systems targeted to deliver the anti-aging ingredients, and a control version without the delivery system technologies). We then evaluated the effect on biological markers via standard Immunohistochemistry (IHC) techniques on ex vivo skin. From these results, it was clear that the formula with the designed delivery systems showed a significant increase in efficacy (and, thus, inferred delivery) for collagen, elastin and hyaluronic acid. Overall, this shows that not only are the active ingredients important to consider, but also tailored delivery systems should be incorporated into the formula to achieve optimized benefits.

ESDR376 - Designing Formulation Systems to Ensure Efficient Delivery of Anti-Aging Actives to Skin for Boosted Efficacy

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING