Lichenoid drug eruptions and Lichen planus are rare dermatological side effects reported post various types of vaccination. Coronavirus disease of 2019 emerged as a pandemic and vaccines have a preventive and therapeutic role to control the infection, reduce morbidity and mortality. The risk of an allergic reaction post-vaccination is estimated to be 1.31 per million vaccine doses. A 71 year old male patient presented with mild itchy raised lesions for 2 weeks. He received his 1st dose of Covishield vaccine 3 weeks before onset of skin lesions. There were well defined lichenoid papules and plaques over face and neck. Multiple well defined erythematous plaques with mild scaling were also seen over trunk, flexures of upper extremities, anterior aspect of legs and feet. Skin biopsy from both sites (forehead and arm), on histopathology showed features consistent with Lichenoid drug eruption. Oral and topical corticosteroids and antihistamines were given. As cessation of the drug remains the mainstay of the treatment, our patient was informed and with that knowledge, he went ahead with vaccination. Patient received 2nd dose of the vaccine (4 weeks after the first dose), and presented a week later with few itchy well defined erythematous plaques with mild scaling seen only over both legs and dorsal aspect of feet. There was resolution of older lesions over upper extremities, trunk, face and neck lesions with some post inflammatory hyperpigmentation. This time the patient was treated only with topical corticosteroids and emollients for 2 weeks with complete resolution. We observed our patient for 3 months after the last exacerbation and since then no new lesions were seen. Given the global vaccination drive, it is important that clinicians be aware of this potential cutaneous adverse effect.

ESDRLB022 - Lichenoid drug eruption eruption post Adenoviral vector (Covishield) vaccine for COVID-19

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING