The imine reductase (IRED) family of enzymes have recently emerged as a diverse set of biocatalysts able to catalyse both imine reduction and reductive amination. leading to their rapid adoption for target molecule synthesis, both in academic laboratories and in industry. We have now discovered that a new sub-group of IREDs can can additionally catalyse conjugate reduction (C=C to C-C). This lecture will discuss both the path leading to the identifcation of these enzymes as well as their recent application for the synthesis of bioactive target molecules.

Discovery and synthetic application of a multi-functional redox enzyme

ACS Fall 2021

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