In the last decade, Heterogeneous catalysis is one of the most significant industrial processes in fabrication of chemicals. It is based on the surface reactions, which shout out for the adsorption of least one of the reactants on the catalyst surface. In recent years, there is great interest towards the use of heterogeneous catalysts in organic synthesis, due to the inherent advantages such as reusability, low cost, and easy work-up.<br/>Heterogeneous catalysts have been used commercially to make heterocyclic compounds for over 80 years; it produced directly from heterogeneously catalyzed processes span commodities through specialties to fine chemicals.<br/>In this work, the synthesis of pyrazole moiety was carried out starting from α,β-insaturated ketones, using an heterogeneous phosphatecatalyst (<b>Fig.1</b>).In the first stage we have synthesized the α,β-ethylenic ketones using Claisen-Schmidt condensation, which consists of reacting acetophenones with benzaldehydes in the presence of a basic catalyst. The second stage, is the cyclocondensation reaction of chalcones with hydrazine in the presence of heterogeneousphosphate catalyst. The pyrazoles structures was obtained with the good yields.

Novel synthesis of pyrazoles by heterogeneous catalyst

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.