A novel method based on solid phase extraction (SPE) was established to extract perfluorooctanoic acid (PFOA) from raw and treated landfill leachate samples. The effect of factors on the recovery rate, such as SPE cartridge, pH value and ionic strength were studied in the research. Response surface methodology (RSM) optimization had been incorporated by using Box-Behnken design (BBD) to develop a model. In this model, the factors such as volume of activator reagent, volume of eluent and ionic strength were taken into account to obtain the anticipated recovery rate of PFOA, and then all samples were analyzed with HPLC–MS/MS system. The model was significant with P &lt; 0.05, and the lack of fit value was not significant to the pure error. The optimum SPE conditions of PFOA from raw and treated landfill leachate were: activating WAX cartridge with 10 mL methanol and 4 mL ultrapure water, pre-adding 600 mg KCl (if the ionic strength of the sample was low), and eluting PFOA with 6 mL 1% ammonia methanol after removing impurities by extraction with 4 mL formic acid. The theory recovery rate was over 95.67% under these optimal SPE conditions. The results showed that the recovery rate of PFOA was 93.34% (RSD=0.28%), and the relative error of prediction value was 2.43%. It concluded that the optimization could perform for the SPE of PFOA from raw and treated landfill leachate.

Optimization of solid-phase extraction conditions of PFOA in landfill leachate by response surface methodology

ACS Fall 2021

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