Dimpropyridaz is a pyrazole carboxamide insecticide currently being developed by BASF. The compound is the first representative of this new chemical class of insecticides and has excellent activity against sucking insects. In our research on pyrazole carboxamide insecticides, we have applied scaffold-hopping approaches to identify new chemotypes by modifying the pyridazine heterocycle with other heterocyclic groups, such as 1,2-diazine and 1,3-pyrimidine, to measure their biological activities and properties. In this presentation, the syntheses, properties and structure-activity trends of these isosteres will be described.

Scaffold-hopping approach to identify new chemotypes of dimpropyridaz

ACS Fall 2021

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