Nanodrugs encapsulated by assembled surfactants are of great significance for targeted delivery and controlled release. Flash nanoprecipitation (FNP) is a powerful method to prepare nanodrugs with the help of surfactant assembly. However, the search for suitable surfactant for drugs with various hydrophobicity is still challenging. Herein, cost-effective and biocompatible surfactant combination of sophorolipids was found to be able to prepare nanodrugs with various hydrophobicity by FNP. The commercial sophorolipids were separated successfully into two components: the acidic and the lactonic sophorolipids. According to the hydrophobicity of the drug, the most suitable combination of the two kinds of sophorolipids can be found by adjusting the ratio of their composition.

Encapsulation drugs with various hydrophobicity using sophorolipids by flash nanoprecipitation

ACS Fall 2021

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