Aqueous systems containing two water soluble polymers can separate into a biphasic system where each phase is enriched in one of the soluble polymers. The boundary between the monophasic and biphasic regions of the phase diagram is dependent on the concentration of the two polymers in solution. This type of phase behavior in polymeric systems, such as mixtures of dextran and polyethylene glycol, is well known and has been applied to the separation of biomolecules. High throughput phase analysis workflows have been developed by Dow, and they are well suited to the characterization of such biphasic systems. Automated image capture and image analysis allow for the quick determination of the boundary between the monophasic and biphasic regions of the phase diagram. Acrylic acid homopolymers and copolymers containing acrylic acid were blended with polyethylene glycol containing polymers, and the phase behavior was investigated. The effect of polymer composition on phase behavior will be discussed.

High throughput characterization of phase behavior in polymeric aqueous two-phase systems

ACS Fall 2021

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