We present recent progress on the way to EFED’s longstanding goal toward refinement, replacement, and reduction (3R) of animal toxicity testing in ecological risk assessment, via retrospective studies of our Guideline data holdings and QSAR methods. Avian Acute Toxicity. Collaborator: People for the Ethical Treatment of Animals (PETA). The five-day avian dietary acute test does not contribute to bottom-line risk conclusions beyond the single oral dose study except for highly bioaccumulative chemicals. Avian Reproduction. Collaborator: PETA. A retrospective comparison of mallard duck and bobwhite quail studies to determine if both are required to characterize chronic risk. Fish Bio-Concentration Factor. Collaborator: National Centre for the Replacement, Refinement and Reduction of Animals in Research. BCF test may be reduced to one dose level to harmonize internationally, except when BCF is expected to approach 1,000. Fish Acute LC50. Collaborator: National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). A retrospective comparison of the 3 routinely tested species to determine if one is consistently more sensitive and whether fewer than three will suffice for assessing acute risk. Fish Acute QSAR. Collaborator: EPA Office of Research & Development. Construction of regression equations that expand pesticide-specific modes of action and structural classes. Fish Reproduction. Collaborator: NICEATM. To evaluate if an acute to chronic toxicity ratio (ACR) can be used to estimate chronic toxicity to fish instead of early-life stage and full life-cycle studies Rat Oral LD50. Collaborators: NICEATM and Humane Society. To determine if the CATMoS acute mammalian toxicity prediction model can replace the rat acute oral toxicity study.

Animal toxicity testing reduction efforts in the environmental fate and effects division (EFED)

ACS Fall 2021

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