Activation of C(sp2)-X bond (X=I, Br, Cl) in the aryl halides is one of the challenging bond activations that underpins the difficulty of arylation reaction from benchtop aryl halides. This study focused on an organic photocatalyst with high excited state oxidation potential that can activate C(sp2)-X bond facilitating a clean but powerful arylation protocol to different organic scaffolds. To that end, a new class of green light absorbing acridiniums was synthesized with a photoredox window wide enough to access the C(sp2)-X bond of aryl halides to generate the corresponding aryl radical. Notably, this newly developed acridiniums are organic photocatalysts acting as photo-reductants involving oxidative quenching process, which is rarely documented for the currently existing acridinium photocatalyst family. We further elaborated this study towards developing an industry viable photoredox protocol emphasizing its applications in the synthesis of bioactive scaffolds and pharmaceutical drug molecules.

Green light acridiniums as photoreductant : Towards an industry viable photoredox protocol

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.