<i>Panax Ginseng C.A. Meyer </i>(PGCAM) is a well-known phytomedicine but most of its compounds like ginsenoside have poor absorption and bioavailability profile due to high molecular weight (≥500 daltons) which is the major hurdle for their clinical application. Hence, this research explored the efficiency of low molecular weight compounds (LMWCs) (&lt;500 daltons) screened from PGCAM and their anti-COVID-19 mechanisms through network pharmacology. Molecular compounds from PGCAM were identified using public databases and filtered out by the drug-likeness evaluation. Genes interacted with these filtered compounds and COVID-19 related genes were extracted from public databases. The key bioactive compounds were documented through virtual screening. The mechanisms of PGCAM against COVID-19 were related to 28 signaling pathways. The key molecular anti-COVID-19 mechanisms might be the anti-inflammation, anti-permeability and pro-apoptosis by inactivating the PI3K-Akt signaling pathway. The six key genes and the five compounds were RELA-paeonol, NFKB1-frutinone A, IL6-nepetin, MCL1-ramalic acid, VEGFA-trifolirhizin and IL2-trifolirhizin.

Potential working mechanisms of low molecular weight compounds of <i>valence bond C.A. Meyer </i>in relieving COVID-19: a network pharmacology analysis

ACS Fall 2021

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Potential working mechanisms of low molecular weight compounds of valence bond C.A. Meyer in relieving COVID-19: a network pharmacology analysis