The processes of gold colloid aggregates were investigated for amyloidogenic peptides (i.e., Amyloid beta 1-40, alpha synuclein, and beta 2 microglobulin). The core size of the gold colloid ranged between 10 nm and 100 nm. The formation of the aggregates were monitored by the red-shift of SPR (Surface Plasmon Resonance) band of gold colloid as the concentration of amyloidogenic peptides were increased with a step of 100 pico-moles. There were two distinct different aggregation processes were observed. One was the gradual aggregation formation as a function of concentration. The other was the step-wise aggregate formation took place at a critical concentration, which was around a couple hundreds of pico-moles of amyloidogenic peptides. As a general trend, relatively smaller diameters (d) of gold colloids (d <u>&lt;</u> 20 nm) supported the gradual aggregates formation. On the contrary, for d <u>&gt;</u> 40 nm, the step-wise aggregate formation was confirmed.

Nano-size dependent aggregates formation of Amyloidogenic peptide coated gold particles

ACS Fall 2021

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