Virus-based therapies have raised significant interest in cancer treatment, prophylactic vaccination, and gene therapy. The features of viruses are leveraged to prevent and treat diseases. Outstanding benefits of virus-based therapies are personalized medicine and the generation of novel therapeutic targets and universal vaccines. Current production processes generate significant amounts of product-related impurities which need to be removed during the purification process. These impurities do not have a therapeutic benefit and are considered a risk for a successful therapy by triggering an immune response. Chromatography has become the method of choice for challenging separations. MilliporeSigma has developed a variety of chromatography materials for the purification of molecules such as monoclonal antibodies, plasma proteins, and novel therapeutic targets. The unique tentacle chemistry of MilliporeSigma Fractogel® and Eshmuno® resins is beneficial for the purification of larger molecules such as viral vaccines, virus-like particles (VLPs) and viral vectors. Here we present data generated with our tentacle-based ion exchange resins for purification of viral vectors e.g. oncolytic measles virus and HIV-1 gag VLP.

V3: Tentacle-based ion exchange resins for viral vaccines, virus-like particles, and viral vector purification

ACS Fall 2021

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