Communication between the nervous system and immune system is vital for maintaining health yet remains difficult to probe with precise temporal and spatial resolution. Our lab uses a combination of electrochemistry and microfabrication techniques to close the current gaps in the field. Specifically, we have developed new electrochemical methods and electrode materials for fast-scan cyclic voltammetry (FSCV) which have enabled us to expand these tools to new important chemical messengers involved in neuroimmune communication including melatonin, guanosine, and Zn which have not been previously studied with real-time electrochemical techniques in tissue. FSCV is a classic electroanalytical technique most often used in the brain to study neurotransmitter signaling on a 100-ms timescale; however, our lab has also expanded its utility to studying neurochemical events in immune organs like the lymph node. In addition, combining FSCV with microengineered platforms has provided us an experimental platform to probe neurotransmitter signaling during focal ischemia as well as in multiple organs simultaneously ex vivo during neuroimmune communication. This talk will highlight some of our recent work in this area on method development and the application of these methods to study neuroimmune signaling within and between the brain and immune system.

Analytical approaches to detect neuroimmune signaling

ACS Fall 2021

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