Extracellular vesicles (EVs), such as exosomes and microvesicles, have the potential to revolutionize the development and efficient delivery of clinical therapeutics.  In this presentation, I will provide a brief introduction to the landscape of exosome-based vectors that are being developed for the delivery of protein- and nucleic acid-based therapeutics.  The talk will highlight some of the most pressing analytical measurement and standardization challenges that are limiting the translation of EVs from the bench to the clinic.  Current challenges limiting the development of EVs for drug delivery are the lack of (1) standardized cell-based platforms for the production of EV-based therapeutics, (2) reference material EV preparations for establishing measurement assurance and (3) standardized analytical methods for determining the molecular composition of EVs.  Examples of potential solutions to the mentioned measurement challenges are deconstructed in terms of global regulatory needs.

Measurement and standardization challenges for extracellular vesicle therapeutic delivery vectors

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.