Gold nano-particles were coated with the spike protein (S protein) of SARS-CoV-2 and their responses were investigated by monitoring the surface plasmon resonance (SPR) band shift. As the pH value externally hopped between pH~3 and pH~10, a behavior of reversible protein folding was observed for particles with diameters (d) <u>&gt;</u>30 nm. Based on the surface coverage ratio analysis, it was concluded that S protein adsorption conformation was impacted by the size of a core nano-gold, where head-to-head dimerized S protein was estimated for d ≤ 80 nm. On the other hand, anti-<i>parallel</i> format was expected for d = 100 nm.

Nano-size dependent adsorption of the SARS-CoV-2 spike protein

ACS Fall 2021

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