Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) was synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as potential application for cancer treatment. Methods: High saturation magnetization monodisperse cubic IONPs (24.5 ± 1.9 nm) were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, the cytotoxic effects of them on HeLa cells was investigated. Results: DMSA functionalized cubic IONPs have a SAR value of 197.4 W/gFe (15.95 kA/m and 488 kHz) and show slight cytotoxicity on HeLa cells when incubated with , and NP/mL for 24 h, 48 h, 72 h. To the best of our knowledge, this is the first study to investigate both cytotoxic effects of DMSA coated cubic IONPs on HeLa cells and hyperthermia performance of those IONPs.

DMSA coated cubic iron oxide magnetic nanoparticles for magnetic hyperthermia

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.