One of the most common types of surface disinfectants are quaternary ammonium compounds (QACs), which are ubiquitously used in hospitals and disinfecting wipes to cleanse a surface of any bacteria, viruses, or fungi. Their overuse, however, has caused a selective pressure for bacterial resistance that threatens their universal antibacterial power. To combat this natural evolution, two complimentary series of amphiphiles have been developed using novel moieties that have not been used in QAC disinfectants prior, affording an opportunity to further develop them into viable strategies to battle the oncoming wave of QAC resistant strains of bacteria.

Complimentary approaches to combating disinfectant resistance through amphiphilic novelty

ACS Fall 2021

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