The carbon-silicon switch strategy has become an important approach for lead generation and lead optimization. It enables the exploration of the chemical space and can lead to new compounds with improved biological activity profiles, physicochemical properties, and target selectivity. This presentation will disclose the design, synthesis, mode of action, computational binding mode and pharmacological optimization of silicon-containing cyflumetofen analogs.

Design, synthesis and pharmacological optimization of silicon-containing acaricide

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.