Pseudomonads employ many strategies to acquire iron, a nutrient essential for their survival. One such strategy is the use of iron-chelating small molecule siderophores such as pyoverdine and pyochelin. Several shunt products from the biosynthesis of pyochelin, dihydroaeruginoic acid, aeruginoic acid, aeruginaldehyde, aeruginol, pyonitrins A-D, as well as a structurally related molecule aerugine, have all been isolated from numerous Pseudomonad extracts. However, their biological implications are largely unknown. We hypothesized that they may play a role in iron homeostasis or have a biological effect on other bacterial species. Herein, we discuss the physiochemical evaluation of these compounds, and disclose for the first time, their ability to bind iron and promote growth in Pseudomonads.

Pyochelin biosynthetic metabolites bind iron and promote growth in pseudomonads demonstrating siderophore like activity

ACS Fall 2021

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