Lanthanide luminescent nanomaterials have been widely investigated as bioimaging and therapeutic agents in recent years due to their superior photostability, tunable emission wavelength (from visible to near-infrared region) and environment responsive optical properties.  In our work, we utilized temperature reponsive property of lanthanide-doped upconversion luminescent materials and developed a series of nanocomposite which combined lanthanide luminescent materials and photothermal materials to detect the microscopic temperature change of nanoparticles. We achieved, for the first time, the measurement of temperature at nanoscale during photothermal cancer therapy by upconversion luminescence. By using temperature feedback upconversion nanocomposites, the features of nanoscale temperature during photothermal therapy were revealed and the temperature information was used to improve therapy accuracy. Furthermore, with the integration of upconversion materials and thermal responsive drug release system. We demonstrated the programming of combination therapy by monitoring the temperature change of nanoparticles. Our works provide insight into the temperature management of photothermal therapy with the help of lanthanide luminescent materials and improve the accuracy and efficacy of the therapy, therefore substantially promoting its development and clinical translation.

Lanthanide luminescent nanocomposite for non-invasive temperature monitoring in vivo

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.