Despite knowledge for over 10 years that P-glycoprotein(P-gp) plays a central role in GI homeostasis, the precise molecular mechanism that controls its regulation and function remains unclear. Since the resident microbiota contribute to tolerance and homeostasis, our studies address how the functional core microbiome governs intestinal homeostasis via maintenance of P-gp by uniting with a key pathway in xenobiotic metabolism, and how loss of this control leads to disease.

Microbiome Regulation of Intestinal P-Glycoprotein in Maintenance of Homeostasis

ACS Fall 2021

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