AgroSpheres has developed the AgriCell technology to deliver active ingredients for crop protection. The AgriCell is a bioparticle created as a byproduct of fermentation of bacterial cells. The significance of the AgriCell is that it can carry proteins and RNA, but is not contaminated by the chromosomal DNA of the parent bacteria cell. Once purified from the total biomass, the AgriCell solution can be stored as a liquid suspension or dried down to a powder. One of the most promising features of the AgriCell technology is its use for the delivery of RNAs for RNA interference. During the fermentation process, dsRNA or siRNA is synthesized within the parent bacterial strain, which is then followed by the production of the AgriCell. The AgriCell is already loaded with the desired RNA and is then purified from the biomass. This one-step synthesis and encapsulation process provides AgroSpheres with a great COGs advantage. The AgriCell can be further processed to withstand various shifts in temperature and pH, providing the active ingredient better protection from environmental conditions and the harsh saliva/gut of an insect. Due to its modularity in encapsulation, release kinetics, and biomolecule synthesis, the AgriCell is a powerful tool for the delivery of active ingredients in agriculture.

AgriCell Platform: Enhanced production, delivery, and uptake of RNA

ACS Fall 2021

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