Iterative exponential growth (IEG) is an efficient, scalable, and convergent strategy for the synthesis of polymers that feature diverse functionality as well as defined stereochemistry, length, and distance between stereogenic centers. With discrete IEG-derived polymers in hand, we have synthesized a new category of polymer-protein conjugates with a controlled conjugation site and size, along with defined stereochemistry and rigidity of polymeric backbones. These discrete conjugates allow us to study the effect of synthetic polymer structure on protein stability, degradation rate under protease, and biological performances of conjugated proteins, which could potentially provide a new approach of controlling biomaterial properties.

Design and synthesis of discrete polymer-protein conjugates

ACS Fall 2021

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