Evolving from gas chromatography with electron-capture detection to liquid chromatography with a variety of possible mass spectrometer (MS) detectors, agrochemicals, specifically pesticides, have been the subject of, and indeed often the motivation for, development of some of the most exquisitely sensitive and specific analytical methodologies for environmental and food samples. Now, the development of <i>nontargeted analysis (NTA)</i> offers a potential game-changing technical and practical challenge to agrochemical risk management. The purpose of this symposium is to provide agrochemical scientists who do risk assessment—as manufacturers, academics, or regulators—with an overview of the potential of the promising techniques of NTA and Emerging Environmental Contaminant (EEC) libraries to impact the understanding and concerns of agrochemical exposures in the environment. Speakers will introduce the technology –-laboratory, cheminformatic, and computational approaches and methodologies—and industry, public health and regulatory scientists will discuss implications especially for pesticides, their metabolites, and formulation ingredients. Discussion will include but will not be limited to the following issues. (1) Will discovery of thousands of new xenobiotics worldwide change the perspective of pesticides as especially problematic chemicals, or will their use intensity continue to keep them in public focus? (2) Will NTA increase concerns about pesticide metabolites and formulation ingredients? (3) Will NTA’s enormous expansion of identified contaminants and their occurrences, combined with Quantitarive Structure-Activity Relationship (QSAR) modeling, allow for improved predictions of environmental fate and exposure or even toxicology and total risk based on chemical structure? The authors will provide overarching conclusions and messages from the session and pose thought-provoking issues for future consideration. This abstract does not reflect USEPA policy.

Nontarget analyses and emerging environmental contaminants: Implications for agrochemical risk assessment - Symposium discussion and Summation

ACS Fall 2021

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