Energy transfer, a process through which excited-state energy from an excited donor (i.e. a photocatalyst) is transferred to a ground-state acceptor, has rapidly emerged as a mild and useful method to generate high-energy intermediates in organic synthesis reactions. However, controlling the reactivity and selectivity of these high-energy intermediates can often be challenging due to the short lifetimes of their excited states. To address this challenge, an energy transfer catalysis strategy has been developed to accomplish a regioselective β C(sp<sup>3</sup>)-H deuteration of alcohols. This mild deuteration strategy allows for deuteration of several biologically-active molecules.

Regioselective C(sp<sup>3</sup>)-H deuteration enabled by energy transfer catalysis

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Regioselective C(sp3)-H deuteration enabled by energy transfer catalysis

Regioselective C(sp³)-H deuteration enabled by energy transfer catalysis