An important scaffold hopping manipulation in the optimization of agrochemical chemistry classes and in the discovery of novel modes of action is the exchange of the molecular parts of a functional group, e.g. by reverting the orientation of an amide, a sulfonamide, a carbamate, an oxime etc (Figure 1).  During this lecture we will go through several successful examples of functional group inversion, which led to highly active herbicides, fungicides and insecticides. Then we will deep dive into an interesting case study, in which the reversion of an amide function delivered a new scaffold with potent efficacy against Oomycetes pathogens.

Reversal of functional groups as a useful tool in crop protection chemistry

ACS Fall 2021

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