Fluorine atom-containing compounds play an important role in pesticide chemistry. As an a kind of important fluorinated heterocycle, trifluoromethylpyridine is an important active fragment and often found in many commercial pesticides (see Fig. 1). It's was the most widely used heterocycle in fluorinated pesticide, and pesticide design. For decades, trifluoromethylpyridine containing compounds have showed promising activity for crop protection, such as antifungal, antiviral, insecticidal, and antibacterial activity. Trifluoromethylpyridine containing derivatives have become one of the hot topics in the discovery of pesticide. Recently, we reported some derivatives containing the fragment of trifluoromethylpyridine showed good antibacterial activities against Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. citri and Ralstonia solanacearum, promising antivral activities on TMV, CMV, as well as the insecticidal activity against plutella xylostella and Heliothis armigera. In this topic, we summarized the agrochemicals containing the trifluoromethylpyridine fragment, the latest progress in this field in our group were also introduced.

Trifluoromethylpyridine: an important active fragment for discovery of new pesticide

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.