In this work we study pathological hallmarks of Alzheimer’s disease by taking advantage of tissue-like neural probes, mesh electronics, that are designed to reflect the brain environment in which they are employed. Mesh electronics are designed to minimize structural, mechanical, and topological differences with brain tissue, which allows for the electrophysiological study of the same individual neurons and their circuits over many months. These data help understand how aging with the presence of different pathological hallmarks of Alzheimer's disease relate to the progression of neuronal and circuit-level dysfunction in rodents, and may be extended to understand the how other biochemical processes can influence neurophysiological changes over long periods of time <i>in vivo</i>.

Design and use of tissue-like neural probes to study the progression of pathological hallmarks of Alzheimer's disease

ACS Fall 2021

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