The tumor microenvironment, where numerous cell types interact to create a distinctive physiology, is characterized by deregulated metabolic features. In the recent years, 3D cancer models have been optimized to more accurately recreate and study the complex mechanisms behind tumor metabolism which supports cancer invasion, progression, and response to treatment. Because of the growing interest in studying in situ these complex systems, the development of novel technologies is critical to overcome the existence difficulties. In this context, surface enhanced Raman scattering (SERS) appears as a useful tool for label-free detection and imaging of diverse molecules of interest among the extracellular components. Herein, we present the application of nanostructured plasmonic substrates comprising micropatterned Au nanoparticle superlattices and 3D-printed hybrid scaffolds, to the precise SERS detection of selected tumor metabolites which shape the cancer landscape.

From 2D assemblies to 3D printed plasmonic sensors

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.