Cross-electrophile coupling, the reductive cross-coupling of carbon electrophiles with other carbon electrophiles, is a relatively recent advance, but has the potential to impact how C-C bonds are made in both medicinal chemistry and process chemistry. Growing out of a series of collaborations with pharmaceutical companies and UW-Madison faculty, these tools have recently been adapted to high-throughput experimentation on the µmol scale as well as flow electrochemistry suitable for consideration in production. Our latest advancements in these areas as well as highlights of new cross-electrophile couplings will be presented.

Cross-electrophile coupling: New C–C bonds the easy way, from small scale to large scale

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.