A summary of studies on the total synthesis and evaluation of the vancomycin family of glycopeptide antibiotics, their ligand binding pocket redesign that addresses the underlying molecular basis of resistance, and their subsequent peripheral tailoring to incorporate added new mechanisms of action will be presented. The efforts have provided potent and especially durable antibiotics in efforts to address the emerging public health problem of antibiotic resistance.

Maxamycins: redesigned vancomycins for resistant bacteria

ACS Fall 2021

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