Capsinoids, the nonpungent analogs of capsaicinoids, are present in the fruit of many Capsicum species and genotypes - typically at low concentrations. Various methods to synthesize capsinoids from precursor molecules have been reported. However, capsinoids are present in the fruit of select genotypes at very high concentrations and such fruit represents a commercial source of these naturally derived compounds. However, to date, no method has been published to efficiently extract and purify capsinoids from Capsicum fruit. Numerous organic solvents such as pentane can be used to successfully extract capsinoids, while steam distillation-derived essential oil contained no detectable capsiate or dihydrocapsiate. A liquid/liquid extraction procedure, utilizing a pentane crude extract and acetonitrile as the extraction solvent, resulted in 26.3 % (wt/wt) capsiate and 19.4 % (wt/wt) dihydrocapsiate for a combined capsinoids yield of 45.7 % (wt/wt). Obtaining a &gt;90 % capsinoid enriched product was also accomplished in bulk using an hp20ss resin system.

Bulk process for purification and enrichment of capsinoids from capsicum sp. fruit

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.