Heterocyclic scaffolds are part of many biologically active compounds used in the pharmaceutical or agrochemical field. Here we present a transition-metal free route to polycyclic molecules via the C-H activation of a substituted triazolium salt under oxidative conditions. While our isolated yields are still moderate for this step, the C-H activation proceeds cleanly and we are confident that we can optimize the heterocycle formation further.

C-H activation of triazolium salts as pathway to extended heterocyclic systems

ACS Fall 2021

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